THE RAJAGOPAL LAB
Publications
Surve MV, Lin B, Reedy JL, Crossen AJ, Xu A, Klein BS, Vyas JM, Rajagopal J. Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells. bioRxiv [Preprint]. 2023 Aug 7:2023.08.06.552176. PMID: 37609222.
Shah VS, Hou J, Vinarsky V, Xu J, Surve MV, Lin CP, Rajagopal J. Autofluorescence imaging permits label-free cell type assignment and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs). Elife. 2023 Mar 30;12:e84375. PMID: 36994985.
Shah VS, Chivukula RR, Lin B, Waghray A, Rajagopal J. Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do? Annu Rev Pathol. 2022 Jan 24;17:23-46. Epub 2021 Aug 26. PMID: 34437820.
Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 Jan 1;371(6524):52-57. PMID: 33384370.
Montoro DT, Haber AL, Rood JE, Regev A, Rajagopal J. A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia. Cold Spring Harb Perspect Biol. 2020 Nov 2;12(11):a035733. PMID: 32122885.
Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 Aug 1; 319–324. PMID: 30069044.
Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018 Mar 26;44(6):679-693.e5.
Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhardt JF, Hsu YC, Rajagopal J. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016 June 16; 217-31.
Pardo-Saganta A, Tata PR, Law BM, Saez B, Chow RDz, Prabhu M, Gridley T, Rajagopal J. Parent stem cells can serve as niches for their daughter cells. Nature. 2015 Jul 30;523(7562):597-601. PMID: 26147083.
Pardo-Saganta A, Law BM, Tata PR, Villoria J, Saez B, Mou H, Zhao R, Rajagopal J. Injury Induces Direct Lineage Segregation of Functionally Distinct Airway Basal Stem/Progenitor Cell Subpopulations. Cell Stem Cell. 2015 Feb 5;16(2):184-197. PMID: 25658372.
Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J. Yap Tunes Airway Epithelial Size and Architecture by regulating the Identity, Maintenance, and Self-renewal of Stem Cells. Developmental Cell. 2014 Jul 28;30(2): 151-65 (Also reviewed in Developmental Cell). PMID: 25043474.
Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed luminal epithelial cells into functional stem cells in vivo. Nature. 2013; 503; 218-223 (highlighted in Nature News and Views and featured in Cell Leading Edge Select and a Cell Stem Cell preview, selected as an F1000 Prime article). PMID: 24196716.
Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs. Cell Stem Cell. 2012 Apr 6;10(4):385-97.
Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008; 455: 627-32.
Rajagopal J, Anderson W, Kume S, Martinez O, Melton D. Insulin Staining of ES Cell Progeny from Insulin Uptake. Science. 2003;299:363.
Rajagopal J, Doudna J, and Szostak J. Stereochemical Course of Catalysis by the Tetrahymena Ribozyme. Science. 1989;244:692-94.